BRONLAST-L TAB

Category Name Respiratory Care — Antihistamine + Leukotriene Receptor Antagonist Combination

Common Indications

• Allergic rhinitis — seasonal and perennial (hay fever)
• Chronic urticaria (hives) and allergic skin reactions
• Bronchial asthma — as add-on maintenance therapy
• Exercise-induced bronchoconstriction
• Allergic conjunctivitis (watery, itchy eyes)
• Post-nasal drip and sneezing associated with allergy
• Aspirin-sensitive asthma

Common Dosing

• Standard Adult Dose: One tablet once daily, preferably in the evening
• Evening dosing is preferred as Levocetirizine may cause mild sedation and Montelukast is best taken at night for asthma control
• Duration: As prescribed — seasonal allergies (short-term) or chronic conditions (long-term)

Always follow your doctor's prescribed dose and duration.

Common Side Effects

• Drowsiness or sedation (Levocetirizine-related)
• Headache
• Dryness in mouth
• Fatigue and weakness
• Nausea or abdominal discomfort
• Mood changes, depression, or anxiety (Montelukast — rare but important)
• Insomnia or nightmares (Montelukast — rare)

Seek immediate attention for:

• Severe mood changes, suicidal ideation, or aggressive behaviour (Montelukast neuropsychiatric effects — rare)
• Severe allergic reactions

Common Interactions

• CNS Depressants, Sedatives, Alcohol — Enhanced drowsiness with Levocetirizine
• Theophylline — May reduce Montelukast plasma levels
• Phenobarbital, Rifampicin — May reduce Montelukast effectiveness via enzyme induction
• Ketoconazole — May increase Montelukast levels

Special Instructions

Mechanism of Action

• Levocetirizine (Second-Generation Antihistamine): Selectively blocks peripheral H1 histamine receptors, reducing histamine-mediated allergic symptoms — runny nose, sneezing, itchy and watery eyes, urticaria. Minimal CNS penetration compared to first-generation antihistamines, causing less sedation
• Montelukast (Leukotriene Receptor Antagonist — LTRA): Selectively blocks cysteinyl leukotriene (CysLT1) receptors, preventing leukotrienes (LTC4, LTD4, LTE4) from binding. Leukotrienes are potent inflammatory mediators that cause bronchoconstriction, mucus secretion, and airway inflammation in asthma and allergic rhinitis. By blocking these receptors, Montelukast reduces airway inflammation, bronchoconstriction, and allergic nasal symptoms

Together they block two distinct and complementary inflammatory pathways — histamine and leukotriene — providing broader and more effective allergy and asthma symptom control.

Instructions to Take

• Take once daily in the evening, preferably at the same time each night
• Can be taken with or without food
• Swallow whole with a full glass of water
• Monitor for any unusual mood or behavioural changes and report to your doctor immediately
• Do not stop Montelukast abruptly if used for asthma maintenance
• If you miss a dose, take as soon as remembered. If it is the next day, skip the missed dose
• Store in a cool, dry place away from sunlight and moisture

This information is intended for general reference purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.