COTHYL-CD3

Category Name Neuro-Nutritional Supplement — Anti-Neuropathy & Metabolic Support Combination Tablet

Common Indications

• Diabetic peripheral neuropathy — numbness, tingling, burning, and pain in feet and hands
• Nutritional and B12 deficiency neuropathy
• Metabolic neuropathy associated with insulin resistance
• Blood sugar regulation support (Chromium, Inositol, Benfotiamine)
• Oxidative stress and nerve damage from free radicals (Alpha Lipoic Acid)
• Bone health support in diabetic and neuropathic patients (Calcium Carbonate + Vitamin D3)
• General neurological support and axonal repair

Common Dosing

• Standard Adult Dose: One tablet once or twice daily, with or after food, or as directed by your doctor
• Duration: Long-term use as prescribed, especially in diabetic neuropathy management

Always follow your doctor's prescribed dose and duration.

Common Side Effects Generally well tolerated. Possible mild effects include:

• Nausea or mild GI discomfort (take with food)
• Mild skin flushing (Alpha Lipoic Acid or Niacinamide-related)
• Headache
• Constipation (Calcium Carbonate component)

Common Interactions

• Antidiabetic drugs — Chromium Picolinate and Benfotiamine may enhance blood glucose lowering; monitor blood sugar
• Levodopa — Pyridoxine (B6) may reduce effectiveness in Parkinson's treatment
• Metformin — Long-term use depletes B12; Methylcobalamin supplementation is beneficial
• Anticonvulsants — May deplete B vitamins and folate; supplementation is supportive
• Iron and Calcium supplements — Separate doses by 2 hours to avoid absorption interference

Special Instructions

Mechanism of Action Each component in Cothyl-CD3 targets a specific aspect of neuropathic and metabolic damage:

• Methylcobalamin (Active B12): Directly supports myelin sheath synthesis and axonal regeneration — the most bioavailable form of B12 for neurological repair
• Alpha Lipoic Acid: Universal antioxidant (both fat and water soluble) that neutralizes free radicals in nerve tissue, regenerates other antioxidants (Vitamins C and E), and improves mitochondrial nerve function
• Benfotiamine (Fat-Soluble B1): Activates the pentose phosphate pathway, reducing advanced glycation end-products (AGEs) that damage nerves in diabetic neuropathy
• Inositol (Myo-Inositol): Improves nerve conduction velocity and insulin signalling; reduces symptoms of peripheral neuropathy
• Chromium Picolinate: Enhances insulin receptor sensitivity, improving cellular glucose utilisation and supporting glycaemic control
• Pyridoxine (B6): Essential cofactor for neurotransmitter synthesis and peripheral nerve function
• Folic Acid: Supports DNA synthesis, homocysteine metabolism, and neuronal repair
• Vitamin D3: Modulates neuroinflammation and supports calcium-dependent nerve signal transmission
• Calcium Carbonate: Provides essential calcium for nerve impulse propagation and bone health

Together they provide comprehensive neuroprotective, antioxidant, and metabolic support — addressing multiple pathways of diabetic and nutritional neuropathy simultaneously.

Instructions to Take

• Take with or after food to minimize GI discomfort
• Take at the same time each day for consistent levels
• Do not exceed the recommended dose
• Monitor blood glucose if on antidiabetic therapy — may enhance glucose-lowering effect
• Allow at least 2 hours between this tablet and iron, antacid, or calcium supplements
• Store in a cool, dry place away from sunlight and moisture

This information is intended for general reference purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.