DEWPRIDE G1 TAB.

Category Name Cardio-Diabetic — Oral Antidiabetic Combination (Sulfonylurea + Biguanide)

Common Indications Dewpride G1 Tablet is used in the management of:

• Type 2 Diabetes Mellitus in adults, where diet and exercise alone are insufficient to control blood sugar levels
• Hyperglycemia (elevated blood glucose) requiring dual oral antidiabetic therapy
• Long-term glycemic control to reduce the risk of diabetes-related complications such as nerve damage, kidney disease, and cardiovascular events
• As an adjunct to lifestyle modifications including diet management and regular physical activity

This medicine is not indicated for Type 1 Diabetes Mellitus or diabetic ketoacidosis.

Common Dosing

• Standard Adult Dose: One tablet once or twice daily, with meals, as prescribed by your doctor
• Starting Dose: Typically initiated at the lowest effective dose and gradually adjusted based on blood glucose response and tolerability
• Dose Adjustment: Your doctor will periodically review and titrate the dose based on HbA1c levels and fasting blood glucose readings
• Missed Dose: If a meal is skipped, do not take the tablet for that meal to avoid the risk of hypoglycemia

Always follow your doctor's prescribed dose and duration. Never self-adjust the dose.

Common Side Effects Most side effects are manageable and tend to improve with continued use. These may include:

• Hypoglycemia (low blood sugar) — the most important side effect; symptoms include sweating, shakiness, dizziness, confusion, and rapid heartbeat
• Nausea
• Diarrhea
• Headache
• Stomach discomfort or loss of appetite (more common during initial weeks of therapy)

Seek immediate medical attention if you experience:

• Severe or persistent low blood sugar episodes
• Unusual muscle pain, difficulty breathing, stomach pain, or extreme weakness — these may be signs of lactic acidosis, a rare but serious condition associated with Metformin
• Yellowing of skin or eyes, or dark urine, which may indicate liver involvement

Report any persistent or worsening side effects to your doctor promptly.

Common Interactions Inform your doctor or pharmacist about all medications, supplements, and herbal products you are currently taking. Notable interactions include:

• Other Antidiabetic Drugs or Insulin — Concurrent use significantly increases the risk of hypoglycemia (dangerously low blood sugar); close blood glucose monitoring is essential
• Alcohol — Enhances the risk of both hypoglycemia and lactic acidosis with Metformin; strictly avoid alcohol during treatment
• Corticosteroids (e.g., Prednisolone, Dexamethasone) — May reduce the blood sugar-lowering effect and cause hyperglycemia; dose adjustment may be needed
• Diuretics (e.g., Furosemide, Hydrochlorothiazide) — May impair glycemic control and increase blood glucose levels
• Oral Contraceptives — May reduce the antidiabetic effectiveness of this combination; blood glucose should be monitored more frequently
• Beta-Blockers (e.g., Atenolol, Propranolol) — May mask early warning symptoms of hypoglycemia such as rapid heartbeat and tremors, making it harder to detect low blood sugar episodes

Special Instructions

Mechanism of Action Dewpride G1 Tablet combines two antidiabetic medicines that work through distinct but complementary mechanisms to achieve effective blood sugar control:

• Glimepiride (Sulfonylurea): Stimulates the beta cells of the pancreas to produce and release more insulin in response to meals. It also improves the sensitivity of peripheral tissues to insulin, helping cells absorb glucose more efficiently from the bloodstream. Its effect is glucose-dependent, meaning it primarily acts when blood sugar is elevated
• Metformin (Biguanide): Works through three key actions — it reduces excess glucose production by the liver (hepatic gluconeogenesis), slows the absorption of glucose from the intestines into the bloodstream, and enhances the body's sensitivity to insulin at the cellular level. Unlike Glimepiride, Metformin does not stimulate insulin secretion and therefore carries a lower standalone risk of hypoglycemia

Together, they provide a dual-action approach — stimulating insulin release while simultaneously reducing glucose production and improving insulin utilization — resulting in superior and sustained blood sugar control.

Instructions to Take

• Take this tablet with or just before a meal to reduce the risk of stomach upset and hypoglycemia
• Do not skip meals after taking this medicine — skipping food after a dose can cause dangerously low blood sugar
• Swallow the tablet whole with a glass of water — do not crush or chew unless advised
• Take it at the same time every day to maintain consistent blood glucose control
• Monitor your blood sugar regularly as advised by your doctor, and keep a log to share during follow-up visits
• Always carry a fast-acting sugar source (glucose tablets, fruit juice, or sugar) in case of a hypoglycemic episode
• Do not stop this medicine abruptly without consulting your doctor, even if you feel well — diabetes requires continuous management
• If you miss a dose at mealtime, skip it entirely for that meal — never double up the next dose
• Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children

This information is intended for general reference purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.