Category Name Anti-Infectives — Extended-Spectrum Penicillin + Beta-Lactamase Inhibitor Combination (IV Injection — Hospital Use)
Common Indications Peplin T 4.5 Injection is used in hospital settings for serious and life-threatening bacterial infections, including:
- Severe hospital-acquired pneumonia and ventilator-associated pneumonia
- Complicated intra-abdominal infections (peritonitis, appendicitis)
- Complicated urinary tract infections and pyelonephritis
- Complicated skin and soft tissue infections including diabetic foot infections
- Bacteraemia (bloodstream infections / sepsis)
- Febrile neutropenia in immunocompromised patients
- Gynaecological infections including pelvic inflammatory disease
- Bone and joint infections caused by susceptible organisms
Common Dosing
- Standard Adult Dose: 4.5 g (Piperacillin 4 g + Tazobactam 0.5 g) administered intravenously every 6–8 hours
- Severe Infections / Febrile Neutropenia: Every 6 hours (4 times daily)
- Administration: As an IV infusion over 30 minutes — administered by trained healthcare professionals only
- Renal Impairment: Dose reduction required based on creatinine clearance
- Duration: 7–14 days or as determined by clinical response and culture sensitivity
For hospital and clinical use only — administered exclusively by trained healthcare professionals.
Common Side Effects
- Nausea, vomiting, and diarrhoea
- Headache and dizziness
- Skin rash or urticaria
- Injection site reactions (pain, phlebitis)
- Elevated liver enzymes
- Hypokalaemia (low potassium) with prolonged use
Seek immediate attention for:
- Anaphylaxis — severe allergic reaction
- Clostridium difficile-associated diarrhoea (bloody/watery stools)
- Seizures (at very high doses in renally impaired patients)
- Severe skin reactions (Stevens-Johnson syndrome — rare)
Common Interactions
- Aminoglycosides (e.g., Gentamicin, Amikacin) — Do not mix in the same IV line; physically incompatible. May be used in combination therapeutically but administered separately
- Vancomycin — Do not co-infuse in same line; incompatible
- Methotrexate — Piperacillin may reduce renal clearance, increasing toxicity
- Anticoagulants (Warfarin, Heparin) — May prolong coagulation times; monitor INR
- Neuromuscular blocking agents — Piperacillin may prolong neuromuscular blockade
Special Instructions
| Condition | Guidance |
|---|---|
| 🤰 Pregnancy | Use only if clearly indicated and benefit outweighs risk. Under strict hospital medical supervision. |
| 🤱 Breastfeeding | Small amounts pass into breast milk. Use under medical supervision; monitor infant. |
| 🍺 Alcohol | Not applicable in inpatient IV setting. |
| 🚗 Driving | Not applicable during inpatient treatment. |
| 🫀 Liver Disease | Use with caution. Monitor liver function with prolonged use. |
| 🫘 Kidney Disease | Dose reduction is mandatory in renal impairment. Monitor renal function closely throughout treatment. |
Mechanism of Action
- Piperacillin (Extended-Spectrum Ureidopenicillin): Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and causing bacterial lysis. Provides broad-spectrum coverage including Gram-positive, Gram-negative, and anaerobic organisms — including Pseudomonas aeruginosa
- Tazobactam (Beta-Lactamase Inhibitor): Irreversibly inhibits a wide range of beta-lactamase enzymes produced by resistant bacteria, protecting Piperacillin from enzymatic degradation and extending its coverage to beta-lactamase-producing resistant organisms
Together they provide one of the broadest antibacterial spectrums available in IV antibiotic therapy, making this combination a cornerstone of empirical therapy for severe infections.
Instructions for Administration
- For hospital use only — prepare and administer under trained medical supervision
- Reconstitute with compatible diluent (Normal Saline or 5% Dextrose) per the product insert
- Administer as an IV infusion over 30 minutes — do not administer as rapid IV bolus
- Do not mix with Aminoglycosides or Vancomycin in the same infusion line
- Inspect solution visually before administration — do not use if discoloured or particulate
- Monitor patient for signs of allergic reaction during initial infusion
- Store unreconstituted vials in a cool, dry place protected from light
This information is intended for general reference purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.
