Category Name Pain Killers / Non-Steroidal Anti-Inflammatory Drug (NSAID)
Common Indications PEROVIL 20 is indicated for the relief of moderate to severe pain and inflammation associated with musculoskeletal and joint conditions. It is commonly prescribed for:
- Osteoarthritis with associated joint pain and stiffness
- Rheumatoid arthritis with joint swelling and inflammation
- Acute musculoskeletal pain and muscle inflammation
- Post-traumatic pain and swelling
- Ankylosing spondylitis and other inflammatory joint disorders
- Short-term management of acute gout attacks
- General pain and swelling in joints and muscles requiring anti-inflammatory therapy
Common Dosings One tablet (20 mg) orally, once daily after food — or as directed by your physician. The dispersible tablet (DT) may be dissolved in a glass of water before consumption for ease of administration. The dose and duration of therapy should be determined by the treating physician based on the condition being treated and the patient's clinical response. Use the lowest effective dose for the shortest duration necessary to control symptoms.
Common Side Effects The following side effects may occur during the course of treatment. Consult your doctor if any of these persist or worsen:
- Headache
- Nausea or vomiting
- Stomach pain or abdominal discomfort
- Dizziness
- Indigestion or heartburn
- Gastric irritation or ulcers with prolonged use
- Signs of gastrointestinal bleeding such as black or tarry stools or vomiting blood — seek immediate medical attention if these occur
- Serious allergic reactions such as facial swelling, difficulty breathing, or severe skin rash — seek immediate medical attention if severe
Common Interactions Inform your doctor about all medications, supplements, and herbal products you are currently taking. Notable interactions include:
- Other NSAIDs / Corticosteroids: Concurrent use significantly increases the risk of gastrointestinal irritation, ulcers, and bleeding — avoid combination use
- Anticoagulants (Warfarin) / Antiplatelet Drugs (Aspirin, Clopidogrel): May further increase the risk of serious bleeding — regular monitoring is strongly recommended
- Antihypertensive Drugs (ACE Inhibitors, Beta-Blockers, Diuretics): Piroxicam may reduce the effectiveness of blood pressure-lowering medications and increase the risk of kidney impairment
- Diuretics / Nephrotoxic Drugs: Concomitant use may increase the risk of renal impairment — use with caution and under close medical supervision
- Lithium: Piroxicam may increase plasma lithium concentrations, raising the risk of lithium toxicity — regular monitoring of lithium levels is advised
- Methotrexate: May increase the plasma concentration and toxicity of methotrexate — concurrent use requires careful clinical monitoring
Special Instructions
| Condition | Guidance |
|---|---|
| Pregnancy | Highly unsafe during pregnancy. May cause serious harm to the unborn baby including birth defects and pregnancy loss. Strictly contraindicated — do not use without explicit medical direction. |
| Breastfeeding | Use with caution during lactation. Consult your doctor before use to assess the benefit-risk profile for both mother and infant. |
| Alcohol | The safety of concurrent alcohol use has not been fully established. Alcohol may increase the risk of gastrointestinal bleeding and stomach irritation — it is advisable to avoid alcohol during therapy. |
| Driving & Machinery | May impair concentration and reaction time in some patients. Avoid driving or operating heavy machinery if you experience dizziness or any symptoms affecting your ability to concentrate and react safely. |
| Liver Disease | Use with caution in patients with hepatic impairment. Regular liver function monitoring may be required — consult your physician before use. |
| Kidney Disease | Use with caution in patients with renal impairment. Piroxicam may further reduce kidney function — dose adjustment and regular renal monitoring may be required. Consult your physician before use. |
Mechanism of Action PEROVIL 20 contains Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) that exerts its therapeutic effect by inhibiting cyclo-oxygenase (COX) enzymes — specifically COX-1 and COX-2 isoenzymes — in body tissues. These enzymes are responsible for the biosynthesis of prostaglandins, which are key chemical mediators of pain, inflammation, and fever. By blocking prostaglandin synthesis at the site of inflammation, Piroxicam effectively reduces pain, swelling, and stiffness in the affected joints and muscles. Its long plasma half-life allows for convenient once-daily dosing while maintaining sustained anti-inflammatory and analgesic activity throughout the day.
Instructions to Take
- Take this tablet exactly as prescribed by your doctor
- Always take after food or with milk to minimise the risk of stomach irritation and gastrointestinal side effects
- The dispersible tablet (DT) may be dissolved in a full glass of water and consumed immediately for ease of swallowing
- Take at the same time each day to maintain consistent drug levels in the body
- Use the lowest effective dose for the shortest duration required to control symptoms
- Do not combine with other NSAIDs, aspirin, or pain-relieving medicines without medical advice
- Do not self-medicate, adjust the dose, or continue therapy beyond the recommended duration without consulting your doctor
- If a dose is missed, take it as soon as you remember — however, skip the missed dose if it is almost time for the next scheduled dose. Do not double the dose to make up for a missed one
- Avoid alcohol throughout the course of treatment
- Keep out of reach of children
- Store in a cool, dry place away from direct sunlight and moisture
Disclaimer: This information is intended for general reference purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.
